For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. For those owners who have difficulty administering tablets to their pets, Denamarin tablet(s) may be disguised in a small bite of food. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Denamarin can be used in conjunction with Marin ^® Plus to provide additional silybin levels and the benefits of vitamin E, zinc, curcumin, and MCT oil supplementation. If Marin Plus is used in conjunction with Denamarin, the two products should be administered 12 hours apart for best response.